Later a single amino acid change, also in a capsid protein, introduced by direct genetic manipulation resulted in a 13,000 to 16,000-fold increased capacity for the phage to remain in the mouse circulatory system.59 Other parameters to improve phage as therapeutic agents, such as production, formulation and route of administration probably fall outside the scope of SB activities, but the lessons learned from previous work with native phages will also apply to SB engineered phages. Interestingly this study also demonstrated that the BRCA1 methylation that silenced breast cancer UACC3199 cell line was also sensitive to PARP inhibition suggesting a wider role for these agents in non-BRCA mutated cancers, and there is emerging clinical evidence to confirm this with the observation by Gelmon et al. For more information on bacterial genetics, bacterial conjugation, bacterial transduction, and bacterial transformation, keep visiting BYJU’S website or download BYJU’S app for further reference. About Science Prof Online. The cells that have the ability to uptake DNA are known as competent cells. 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